Yes. The garment is unisex so that male and female dogs can go to the bathroom without having to adjust the garment. Females have absolutely no problems. Males, due to their different anatomy, can have the abdominal zipper slightly undone to prevent them from urinating into the garment. The zipper is a non-travel/locking zipper. There is 1 exception; Males that are using an abdominal panel. The panel must be removed to allow urination. In general, females can still completely go to the bathroom with the abdominal panel in place.